Sleep Fragmentation Chamber

Model 80391

 

The Sleep Fragmentation Chamber is suitable for sleep deprivation and sleep fragmentation studies in rats and mice. System replaces the Model 80390 Sleep Deprivation Chamber.

 

The Model 80391 Sleep Fragmentation Chamber is used to provide researchers with the necessary tools for sleep fragmentation studies in both mice and rats. The 80391 maintains an animal environment that is virtually identical to that used in the original 80390 Chamber.  The divider wall has been removed since a much faster sweep time is now possible.  The sweep bar, food hopper, ad lib water and ventilated lid remain the same.  The living environment is now independent of the drive mechanism to reduce noise and greatly facilitate cleaning.  It resembles a standard living environment that includes food and water support.  The height of the sweeper bar is adjustable to accommodate bedding.

The cycle time selector includes a variety of different cycle times.  The continuous sweep setting now takes just 7.5 seconds.  Selectable inter-sweep cycle values start at 0.25 minutes (15 seconds) all the way up to 30 minutes.  Alternately, sweeps may be initiated from a remote device.

Sleep Fragmentation Bar


Specifications

Power Supply

  • 9 VDC @ 2A center positive supply (included)

Cycle Times

  • Continuous: Approximately 7.5 seconds
  • Selectable (min): 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 10, 15, 20, 25, 30

External Initiate / Event Output

  • General: 2.5mm connection, 3 conductor
  • Base: Ground
  • Ring: Event Out - Open collector, Pull up if needed (30 VDC max)
  • Tip: Ext Initiate, active low switch closure

Dimensions

  • Outside: 16.0”L x 10.5”W x 14.5” H (40.6 x 26.7 x 36.8 cm)
  • Inside Living Space: 9.24”L x 7.49”W x 7.52”H (23.5 x 19.0 x 19.1 cm)
  • Weight: 12 lbs (5.4 kilograms)

Science

Blackwell, A. A., Tracz, J. A., Fesshaye, A. S., Tidmore, A., Osterlund Oltmanns, J. R., Schaeffer, E. A., Lake, R. I., Wallace, D. G., & Britten, R. A. (2023). Fine motor deficits exhibited in rat string-pulling behavior following exposure to sleep fragmentation and deep space radiation. Experimental Brain Research, 241(2), 427-440. Read More

Nguyen, V. T., Fields, C. J., & Ashley, N. T. (2023). Temporal dynamics of pro-inflammatory cytokines and serum corticosterone following acute sleep fragmentation in male mice. PLOS ONE, 18(12), e0288889. Read More

Puech, C., Badran, M., Barrow, M. B., Runion, A. R., & Gozal, D. (2023). Solriamfetol improves chronic sleep fragmentation-induced increases in sleep propensity and ameliorates explicit memory in male mice. SLEEP, 46(5). Read More

Puech, C., Badran, M., Runion, A. R., Barrow, M. B., Cataldo, K., & Gozal, D. (2023). Cognitive Impairments, Neuroinflammation and Blood-Brain Barrier Permeability in Mice Exposed to Chronic Sleep Fragmentation during the Daylight Period. International Journal of Molecular Sciences, 24(12), 9880. Read More

Wang, C., Nambiar, A., Strickland, M. R., Lee, C., Parhizkar, S., Moore, A. C., Musiek, E. S., Ulrich, J. D., & Holtzman, D. M. (2023). APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading. Journal of Clinical Investigation, 133(14). Read More

Ensminger, D. C., Wheeler, N. D., al Makki, R., Eads, K. N., & Ashley, N. T. (2022). Contrasting effects of sleep fragmentation and angiotensin-II treatment upon pro-inflammatory responses of mice. Scientific Reports, 12(1), 14763. Read More

Guo, L., Reed, K. M., Carter, A., Cheng, Y., Roodsari, S. K., Martinez Pineda, D., Wellman, L. L., Sanford, L. D., & Guo, M.-L. (2022). Sleep-Disturbance-Induced Microglial Activation Involves CRH-Mediated Galectin 3 and Autophagy Dysregulation. Cells, 12(1), 160. Read More

Heyde, A., Rohde, D., McAlpine, C. S., Zhang, S., Hoyer, F. F., Gerold, J. M., Cheek, D., Iwamoto, Y., Schloss, M. J., Vandoorne, K., Iborra-Egea, O., Mu?oz-Guijosa, C., Bayes-Genis, A., Reiter, J. G., Craig, M., Swirski, F. K., Nahrendorf, M., Nowak, M. A., & Naxerova, K. (2021). Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis. Cell, 184(5), 1348-1361.e22. Read More

Mishra, I., Pullum, K. B., Thayer, D. C., Plummer, E. R., Conkright, B. W., Morris, A. J., O'Hara, B. F., Demas, G. E., & Ashley, N. T. (2020). Chemical sympathectomy reduces peripheral inflammatory responses to acute and chronic sleep fragmentation. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 318(4), R781-R789. Read More

McAlpine, C. S., Kiss, M. G., Rattik, S., He, S., Vassalli, A., Valet, C., Anzai, A., Chan, C. T., Mindur, J. E., Kahles, F., Poller, W. C., Frodermann, V., Fenn, A. M., Gregory, A. F., Halle, L., Iwamoto, Y., Hoyer, F. F., Binder, C. J., Libby, P., ... Swirski, F. K. (2019). Sleep modulates haematopoiesis and protects against atherosclerosis. Nature, 566(7744), 383-387. Read More

McLain, J. M., Alami, W. H., Glovak, Z. T., Cooley, C. R., Burke, S. J., Collier, J. J., Baghdoyan, H. A., Karlstad, M. D., & Lydic, R. (2018). Sleep fragmentation delays wound healing in a mouse model of type 2 diabetes. Sleep. Read More

Chopra, S., Polotsky, V. Y., & Jun, J. C. (2016). Sleep Apnea Research in Animals. Past, Present, and Future. American Journal of Respiratory Cell and Molecular Biology, 54(3), 299-305. Read More

Cortese, R., Khalyfa, A., Bao, R., Andrade, J., & Gozal, D. (2015). Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation. International Journal of Obesity, 39(7), 1135-1142. Read More

Dumaine, J. E., & Ashley, N. T. (2015). Acute sleep fragmentation induces tissue-specific changes in cytokine gene expression and increases serum corticosterone concentration. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 308(12), R1062-R1069. Read More

Mutskov, V., Khalyfa, A., Wang, Y., Carreras, A., Nobrega, M. A., & Gozal, D. (2015). Early-life physical activity reverses metabolic and Foxo1 epigenetic misregulation induced by gestational sleep disturbance. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 308(5), R419-R430. Read More

Zheng, J., Almendros, I., Wang, Y., Zhang, S. X., Carreras, A., Qiao, Z., & Gozal, D. (2015). Reduced NADPH oxidase type 2 activity mediates sleep fragmentation-induced effects on TC1 tumors in mice. OncoImmunology, 4(2), e976057. Read More

Wang, Y., Carreras, A., Lee, S., Hakim, F., Zhang, S. X., Nair, D., Ye, H., & Gozal, D. (2014). Chronic sleep fragmentation promotes obesity in young adult mice. Obesity, 22(3), 758-762. Read More

Zhang, S. X. L., Khalyfa, A., Wang, Y., Carreras, A., Hakim, F., Neel, B. A., Brady, M. J., Qiao, Z., Hirotsu, C., & Gozal, D. (2014). Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice. International Journal of Obesity, 38(4), 619-624. Read More

Gharib, S. A., Khalyfa, A., Abdelkarim, A., Bhushan, B., & Gozal, D. (2012). Integrative miRNA-mRNA profiling of adipose tissue unravels transcriptional circuits induced by sleep fragmentation. PloS One, 7(5), e37669. Read More

Kaushal, N., Nair, D., Gozal, D., & Ramesh, V. (2012). Socially isolated mice exhibit a blunted homeostatic sleep response to acute sleep deprivation compared to socially paired mice. Brain Research, 1454, 65-79. Read More

Kaushal, N., Ramesh, V., & Gozal, D. (2012a). Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 303(1), R19-R29. Read More

Kaushal, N., Ramesh, V., & Gozal, D. (2012b). TNF-α and Temporal Changes in Sleep Architecture in Mice Exposed to Sleep Fragmentation. PLoS ONE, 7(9), e45610. Read More

Ramesh, V., Nair, D., Zhang, S. X. L., Hakim, F., Kaushal, N., Kayali, F., Wang, Y., Li, R. C., Carreras, A., & Gozal, D. (2012). Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway. Journal of Neuroinflammation, 9(1), 601. Read More

Nair, D., Zhang, S. X. L., Ramesh, V., Hakim, F., Kaushal, N., Wang, Y., & Gozal, D. (2011). Sleep Fragmentation Induces Cognitive Deficits Via Nicotinamide Adenine Dinucleotide Phosphate Oxidase-dependent Pathways in Mouse. American Journal of Respiratory and Critical Care Medicine, 184(11), 1305-1312. Read More

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