Progressive Ratio and Effort Related Choice Task (PR/ERC) for Mice
Model 89549A
Adapted for mice, this touch screen task has been shown equivalent to those performed with levers or nose-poke holes in measuring motivation and reward-related decision making.
Measuring motivation and reward-related decision making, this touch screen task has been shown equivalent to those performed with levers or nose-poke holes. Subjects must touch the screen progressively more times to receive reward. Comparing the touch screen results with the non-touch screen literature it is evident that the touch screen paradigm produces less variable data (consequently, easier to detect significant effects) and is more sensitive to manipulations which promote PR performance (useful when screening for drugs to alleviate low motivation).
Example Neural Systems Involved
- Dopamine
Clinical Areas Showing Impairment
- Huntington's
- Schizophrenia
Cognitive Functions Covered
- Motivation
- Decision making
Typical Training Times (depends on strain and age)
- About 16 sessions from first habituation to reach stable PR performance
Features
- A test of motivation and reward-related decision making
- All training paradigms and advice included
Science
Kljakic, O., Jan?čkov?, H., Skirzewski, M., Reichelt, A., Memar, S., Mestikawy, S. El, Li, Y., Saksida, L. M., Bussey, T. J., Prado, V. F., & Prado, M. A. M. (2022). Functional dissociation of behavioral effects from acetylcholine and glutamate released from cholinergic striatal interneurons. The FASEB Journal, 36(2), e22135. - Abstract
DeBrosse, A. C., Wheeler, A. M., Barrow, J. C., & Carr, G. V. (2020). Inhibition of Catechol-O-methyltransferase Does Not Alter Effort-Related Choice Behavior in a Fixed Ratio/Concurrent Chow Task in Male Mice. Frontiers in Behavioral Neuroscience, 14. - Abstract
Kim, E., White, M. A., Phillips, B. U., Lopez-Cruz, L., Kim, H., Heath, C. J., Lee, J. E., Saksida, L. M., Sreedharan, J., & Bussey, T. J. (2020). Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS?FTD. Translational Psychiatry, 10(1). - Abstract
Hailwood, J. M., Heath, C. J., Phillips, B. U., Robbins, T. W., Saksida, L. M., & Bussey, T. J. (2019). Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation. Neuropsychopharmacology, 44(6), 1068?1075. - Abstract
Heath, C. J., O'Callaghan, C., Mason, S. L., Phillips, B. U., Saksida, L. M., Robbins, T. W., Barker, R. A., Bussey, T. J., & Sahakian, B. J. (2019). A Touchscreen Motivation Assessment Evaluated in Huntington's Disease Patients and R6/1 Model Mice. Frontiers in Neurology, 10. - Abstract
Lim, J., Kim, E., Noh, H. J., Kang, S., Phillips, B. U., Kim, D. G., Bussey, T. J., Saksida, L., Heath, C. J., & Kim, C. H. (2019). Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses. Molecular Brain, 12(1). - Abstract
Hailwood, J. M., Heath, C. J., Robbins, T. W., Saksida, L. M., & Bussey, T. J. (2018). Validation and optimisation of a touchscreen progressive ratio test of motivation in male rats. Psychopharmacology, 235(9), 2739?2753. - Abstract
Kim, E. W., Phillips, B. U., Heath, C. J., Cho, S. Y., Kim, H., Sreedharan, J., Song, H. T., Lee, J. E., Bussey, T. J., Kim, C. H., Kim, E., & Saksida, L. M. (2017). Optimizing reproducibility of operant testing through reinforcer standardization: Identification of key nutritional constituents determining reward strength in touchscreens. Molecular Brain, 10(1). - Abstract
Heath, Christopher J.; Bussey, Timothy J; Saksida, L. M. (2015). Touchscreen Assessment of Motivation and Reinforcement-Related Choice Behaviour in Mice. Psychopharmacology, 232(21?22), 4043?4057. - Abstract
Heath, C. J., Bussey, T. J., & Saksida, L. M. (2015). Motivational assessment of mice using the touchscreen operant testing system: Effects of dopaminergic drugs. Psychopharmacology, 232(21?22), 4043?4057. - Abstract
