Probabilistic Reversal Learning (PRL) for Rats

Model 89553A-R

 

Adapted for rats. Designed to measure sensitivity to valence feedback information, PRL is sensitive to serotonergic manipulations, suggesting this test may be used to study depression-relevant behavior.

 

Designed to measure sensitivity to valence (i.e. positive and negative) feedback information, PRL is sensitive to serotonergic manipulations, suggesting this test may be used to study depression-relevant behaviour in rodents

Example Neural Systems Involved

  • Serotonin

Clinical Areas Showing Impairment

  • Depression

Cognitive Functions Covered

  • Emotional cognition and responding to reinforcement

Typical Training Times (depends on strain and age)

  • 1-2 weeks to train to touch the screen and initiate the task
  • ~17 sessions training to the task

Features

  • A test of sensitivity to positive and negative feedback
  • All training paradigms and advice included
  • Use flexi-shelf in rat chamber

Science

Wilkinson, M. P., Grogan, J. P., Mellor, J. R., & Robinson, E. S. J. (2020). Comparison of conventional and rapid-acting antidepressants in a rodent probabilistic reversal learning task. Brain and Neuroscience Advances, 4, 239821282090717. - Abstract

Phillips, B. U., Dewan, S., Nilsson, S. R. O., Robbins, T. W., Heath, C. J., Saksida, L. M., Bussey, T. J., & Alsi?, J. (2018). Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice. Psychopharmacology, 235(7), 2101?2111. - Abstract


Accessories

Required Accessories

Second Generation Bussey-Saksida Touch Screen Chamber for Rats
Second Generation Bussey-Saksida Touch Screen Chamber for Rats
Model 80604A

The Second Generation Bussey Chambers with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.

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