Probabilistic Reversal Learning (PRL) for Rats
Model 89553A-R
Adapted for rats. Designed to measure sensitivity to valence feedback information, PRL is sensitive to serotonergic manipulations, suggesting this test may be used to study depression-relevant behavior.
Designed to measure sensitivity to valence (i.e. positive and negative) feedback information, PRL is sensitive to serotonergic manipulations, suggesting this test may be used to study depression-relevant behaviour in rodents
Example Neural Systems Involved
- Serotonin
Clinical Areas Showing Impairment
- Depression
Cognitive Functions Covered
- Emotional cognition and responding to reinforcement
Typical Training Times (depends on strain and age)
- 1-2 weeks to train to touch the screen and initiate the task
- ~17 sessions training to the task
Features
- A test of sensitivity to positive and negative feedback
- All training paradigms and advice included
- Use flexi-shelf in rat chamber
Science
Wilkinson, M. P., Grogan, J. P., Mellor, J. R., & Robinson, E. S. J. (2020). Comparison of conventional and rapid-acting antidepressants in a rodent probabilistic reversal learning task. Brain and Neuroscience Advances, 4, 239821282090717. - Abstract
Phillips, B. U., Dewan, S., Nilsson, S. R. O., Robbins, T. W., Heath, C. J., Saksida, L. M., Bussey, T. J., & Alsi?, J. (2018). Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice. Psychopharmacology, 235(7), 2101?2111. - Abstract
