Probabilistic Reversal Learning (PRL) for Mice
Model 89553A
Adapted for mice. Designed to measure sensitivity to valence feedback information, PRL is sensitive to serotonergic manipulations, suggesting this test may be used to study depression-relevant behavior.
Designed to measure sensitivity to valence (i.e. positive and negative) feedback information, PRL is sensitive to serotonergic manipulations, suggesting this test may be used to study depression-relevant behaviour in rodents
Example Neural Systems Involved
- Serotonin
Clinical Areas Showing Impairment
- Depression
Cognitive Functions Covered
- Emotional cognition and responding to reinforcement
Typical Training Times (depends on strain and age)
- 1-2 weeks to train to touch the screen and initiate the task
- ~17 sessions training to the task
Features
- A test of sensitivity to positive and negative feedback
- All training paradigms and advice included
Science
Wilkinson, M. P., Grogan, J. P., Mellor, J. R., & Robinson, E. S. J. (2020). Comparison of conventional and rapid-acting antidepressants in a rodent probabilistic reversal learning task. Brain and Neuroscience Advances, 4, 239821282090717. - Abstract
Phillips, B. U., Dewan, S., Nilsson, S. R. O., Robbins, T. W., Heath, C. J., Saksida, L. M., Bussey, T. J., & Alsi?, J. (2018). Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice. Psychopharmacology, 235(7), 2101?2111. - Abstract
