Location Discrimination (LD) for Rats

Model 89546A-R

 

Adapted for rats, this is a spatial memory task with a reversal learning component. It is sensitive to hippocampal lesions and associated with glutamate receptor regulation and signaling.

 

The rodents are required to discriminate between two white squares on the screen. Responses to squares on one side of the screen will be rewarded, while responses on the other side of the screen will be punished with a time out period. The distance between the two squares is varied from trial to trial. Animals with lesions in the dorsal hippocampus were impaired when the locations were close together, but not when they were far apart. Once 7 out of 8 trials are responded to correctly, the correct side is reversed, adding a reversal learning component. It is sensitive to hippocampal lesions and associated with glutamate receptor regulation and signalling.

Example Neural Systems Involved

  • Hippocampus
  • Neurogenesis

Clinical Areas Showing Impairment

  • Schizophrenia
  • Alzheimers's

Cognitive Functions Covered

  • Learning and Memory
  • Location Discrimination / Pattern Separation

Typical Training Times (depends on strain and age)

  • 1-2 weeks to train to touch the screen and initiate the task
  • 10-20 sessions

 


Sample Video

Mouse

A mouse performing the Location Discrimination for Rodents (LD), using the bottom 6 windows in the 12 window mask.


Features

  • A spatial memory task with a reversal learning component.
  • All training paradigms and advice included
  • Use flexi-shelf in rat chamber for improved performance (reduces impulsive responses from the rat)

Science

Palmer, D., Dumont, J. R., Dexter, T. D., Prado, M. A. M., Finger, E., Bussey, T. J., & Saksida, L. M. (2021). Touchscreen cognitive testing: Cross-species translation and co-clinical trials in neurodegenerative and neuropsychiatric disease. In Neurobiology of Learning and Memory (Vol. 182, p. 107443). - Abstract

Yoo, S., Stremlau, M., Pinto, A., Woo, H., van Praag, H., & Curtis, O. (2021). Effects of combined anti-hypertensive and statin treatment on memory, fear extinction, adult neurogenesis, and angiogenesis in adult and middle-aged mice. Cells, 10(7), 1778. - Abstract

Trammell, T. S., Henderson, N. L., Madkour, H. S., Stanwood, G. D., & Graham, D. L. (2020). GLP-1R activation alters performance in cognitive tasks in a sex-dependent manner. Neurological Sciences. - Abstract


Accessories

Required Accessories

Second Generation Bussey-Saksida Touch Screen Chamber for Rats
Second Generation Bussey-Saksida Touch Screen Chamber for Rats
Model 80604A

The Second Generation Bussey Chambers with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.


Related Products

Location Discrimination (LD) for Mice
Location Discrimination (LD) for Mice
Model 89546A

Adapted for mice, this is a spatial memory task with a reversal learning component. It is sensitive to hippocampal lesions and associated with glutamate receptor regulation and signaling.

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