Extinction (EXT) for Mice
Model 89547A
Adapted for mice, this is a simple, but powerful, test of behavioral inhibition.
The task is very simple, but powerful. Like reversal, it is a test of behavioural inhibition, but with different requirements. In fact, some animals are impaired on reversal, but not extinction, and vice versa. Subjects are first required to respond to a white square presented in the centre window to obtain reward. Once criterion is reached, extinction of the response is tested in sessions where responses to the stimulus are no longer rewarded.
Example Neural Systems Involved
- Infralimbic Cortex
- Striatum
- AmygdalaPerirhinal Cortex
Clinical Areas Showing Impairment
- ADHD
- OCD
Cognitive Functions Covered
- Cognitive Flexibility and Response Inhibition
- Executive Function
Typical Training Times (depends on strain and age)
- Approximately 4 sessions training plus a few extinction sessions
Features
- A test of behavioral inhibition
- All training paradigms and advice included
Science
Kljakic, O., Janíčková, H., Skirzewski, M., Reichelt, A., Memar, S., Mestikawy, S. El, Li, Y., Saksida, L. M., Bussey, T. J., Prado, V. F., & Prado, M. A. M. (2022). Functional dissociation of behavioral effects from acetylcholine and glutamate released from cholinergic striatal interneurons. The FASEB Journal, 36(2), e22135. - Abstract
Luo, J., Tan, J., & Nithianantharajah, J. (2020). Associative Learning and Motivation Differentially Requires Neuroligin-1 at Excitatory Synapses. BioRxiv, 2020.01.01.890798. - Abstract
Kim, E., White, M. A., Phillips, B. U., Lopez-Cruz, L., Kim, H., Heath, C. J., Lee, J. E., Saksida, L. M., Sreedharan, J., & Bussey, T. J. (2020). Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS-FTD. Translational Psychiatry, 10(1). - Abstract
Lim, J., Kim, E., Noh, H. J., Kang, S., Phillips, B. U., Kim, D. G., Bussey, T. J., Saksida, L., Heath, C. J., & Kim, C. H. (2019). Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses. Molecular Brain, 12(1). - Abstract
Dam, S. A., Jager, A., Oomen, C. A., Buitelaar, J. K., Arias-Vasquez, A., & Glennon, J. C. (2019). Inhibitory control in BALB/c mice sub-strains during extinction learning. European Neuropsychopharmacology, 29(4), 509-518. - Abstract
Cho, B. R., Kwak, M. J., Kim, W. Y., & Kim, J. H. (2018). Impulsive action and impulsive choice are differentially expressed in rats depending on the age at exposure to a gambling task. Frontiers in Psychiatry, 9(OCT), 503. - Abstract
Brigman, J. L., Feyder, M., Saksida, L. M., Bussey, T. J., Mishina, M., & Holmes, A. (2008). Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit. Learning & Memory (Cold Spring Harbor, N.Y.), 15(2), 50-54. - Abstract
