Extinction (EXT) for Rats

Model 89547A-R

 

Adapted for rats, this is a simple, but powerful, test of behavioral inhibition.

 

The task is very simple, but powerful. Like reversal, it is a test of behavioural inhibition, but with different requirements. In fact, some animals are impaired on reversal, but not extinction, and vice versa. Subjects are first required to respond to a white square presented in the centre window to obtain reward. Once criterion is reached, extinction of the response is tested in sessions where responses to the stimulus are no longer rewarded.

Example Neural Systems Involved

  • Infralimbic Cortex
  • Striatum
  • AmygdalaPerirhinal Cortex

Clinical Areas Showing Impairment

  • ADHD
  • OCD

Cognitive Functions Covered

  • Cognitive Flexibility and Response Inhibition
  • Executive Function

Typical Training Times (depends on strain and age)

  • Approximately 4 sessions training plus a few extinction sessions

Features

  • A test of behavioural inhibition
  • All training paradigms and advice included
  • Uses flexi-shelf in rat chamber

Science

Kljakic, O., Jan?čkov?, H., Skirzewski, M., Reichelt, A., Memar, S., Mestikawy, S. El, Li, Y., Saksida, L. M., Bussey, T. J., Prado, V. F., & Prado, M. A. M. (2022). Functional dissociation of behavioral effects from acetylcholine and glutamate released from cholinergic striatal interneurons. The FASEB Journal, 36(2), e22135. - Abstract

Luo, J., Tan, J., & Nithianantharajah, J. (2020). Associative Learning and Motivation Differentially Requires Neuroligin-1 at Excitatory Synapses. BioRxiv, 2020.01.01.890798. - Abstract

Kim, E., White, M. A., Phillips, B. U., Lopez-Cruz, L., Kim, H., Heath, C. J., Lee, J. E., Saksida, L. M., Sreedharan, J., & Bussey, T. J. (2020). Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS-FTD. Translational Psychiatry, 10(1). - Abstract

Lim, J., Kim, E., Noh, H. J., Kang, S., Phillips, B. U., Kim, D. G., Bussey, T. J., Saksida, L., Heath, C. J., & Kim, C. H. (2019). Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses. Molecular Brain, 12(1). - Abstract

Dam, S. A., Jager, A., Oomen, C. A., Buitelaar, J. K., Arias-Vasquez, A., & Glennon, J. C. (2019). Inhibitory control in BALB/c mice sub-strains during extinction learning. European Neuropsychopharmacology, 29(4), 509-518. - Abstract

Cho, B. R., Kwak, M. J., Kim, W. Y., & Kim, J. H. (2018). Impulsive action and impulsive choice are differentially expressed in rats depending on the age at exposure to a gambling task. Frontiers in Psychiatry, 9(OCT), 503. - Abstract

Brigman, J. L., Feyder, M., Saksida, L. M., Bussey, T. J., Mishina, M., & Holmes, A. (2008). Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit. Learning & Memory (Cold Spring Harbor, N.Y.), 15(2), 50-54. - Abstract


Accessories

Required Accessories

Second Generation Bussey-Saksida Touch Screen Chamber for Rats
Second Generation Bussey-Saksida Touch Screen Chamber for Rats
Model 80604A

The Second Generation Bussey Chambers with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.

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