5-Choice Continuous Performance Test (5C-CPT) for Mice

Model 89548A

 

Adapted for mice, this go/no-go task measures both attentional and inhibitory systems within a single task paradigm, enabling the assessment of vigilance.

 

Like the 5-choice serial reaction task, this task requires the rodent to respond to a brief visual stimulus presented randomly in one of 5 locations. In addition. some trials present visual stimuli in all five locations together and for these trials the subject must learn to withhold a response. This go/no-go task measures both attentional and inhibitory systems within a single task paradigm, enabling the assessment of vigilance.

Example Neural Systems Involved

  • Dopamine
  • Serotonin
  • Cholinergic
  • Parietal
  • Muscarinic

Clinical Areas Showing Impairment

  • Alzheimer's
  • Schizophrenia
  • ADHD
  • OCD

Cognitive Functions Covered

  • Impulsivity
  • Attention
  • Cognitive Flexibility and response inhibition

Typical Training Times (depends on strain and age)

  • ~ 30 sessions

Features

  • A test of attention and behavioral inhibition
  • All training paradigms and advice included

Science

Cavanagh, J. F., Gregg, D., Light, G. A., Olguin, S. L., Sharp, R. F., Bismark, A. W., Bhakta, S. G., Swerdlow, N. R., Brigman, J. L., & Young, J. W. (2021). Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms. Translational Psychiatry 2021 11:1, 11(1), 1-11. - Abstract

Braeckman, K., Descamps, B., Vanhove, C., & Caeyenberghs, K. (2019). Exploratory relationships between cognitive improvements and training induced plasticity in hippocampus and cingulum in a rat model of mild traumatic brain injury: a diffusion MRI study. Brain Imaging and Behavior. - Abstract

Arulsamy, A., Corrigan, F., & Collins-Praino, L. E. (2019). Age, but not severity of injury, mediates decline in executive function: Validation of the rodent touchscreen paradigm for preclinical models of traumatic brain injury. Behavioural Brain Research, 368. - Abstract

Braeckman, K., Descamps, B., Caeyenberghs, K., & Vanhove, C. (2018). Longitudinal DTI changes following cognitive training therapy in a mild traumatic brain injury rat model. Frontiers in Neuroscience, 12. - Abstract


Accessories

Required Accessories

Second Generation Bussey-Saksida Touch Screen Chamber for Mice
Second Generation Bussey-Saksida Touch Screen Chamber for Mice
Model 80614A

Second Generation Bussey Chamber developed for mice with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.

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