4-Choice Gambling Task (4C-GT) for Rats

Model 89550A-R

 

Adapted for rats, this test is based on the Iowa Gambling Task, sensitive to serotonergic and dopaminergic agents.

 

Based on the Iowa Gambling Task, the rodent chooses from four illuminated windows. A touch in any of the windows will result in either a Win (food reward is delivered) or a Loss (timeout period with no reward). Each window is associated with a different amount of reward. The larger the associated reward, the lower the probability of receiving a Win and the longer the timeout if the trial results in a Loss. The subject must learn to avoid the high-risk, high-reward options in order to maximize earnings. The test is sensitive to serotonergic and dopaminergic agents.

Example Neural Systems Involved

  • Dopamine
  • Serotonin

Clinical Areas Showing Impairment

  • Bipolar Disorder
  • Gambling
  • Depression
  • OCD
  • ADHD
  • Parkinson's
  • Schizophrenia

Cognitive Functions Covered

  • Impulsivity
  • Decision making

Typical Training Times (depends on strain and age)

  • 1-2 weeks to train to touch the screen and initiate the task
  • 4 sessions familiarizing with choices available
  • ~13 sessions testing

Features

  • A test of impulsivity and decision making
  • All training paradigms and advice included

Science

Openshaw, R. L., Pratt, J. A., & Morris, B. J. (2022). The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task. Disease Models & Mechanisms, 15(3). - Abstract

Humby, T., Smith, G. E., Small, R., Davies, W., Carter, J., Bentley, C. A., Winstanley, C. A., Rogers, R. D., & Wilkinson, L. S. (2020). Effects of 5-HT 2C, 5-HT 1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology, 237(6), 1745–1756. - Abstract

Cho, B. R., Kwak, M. J., Kim, W. Y., & Kim, J. H. (2018). Impulsive action and impulsive choice are differentially expressed in rats depending on the age at exposure to a gambling task. Frontiers in Psychiatry, 9(OCT), 503. - Abstract

Coba MP, Komiyama NH, Nithianantharajah J, et al. (2012) TNiK is required for postsynaptic and nuclear signalling pathways and cognitive function. J Neurosci.; 32(40):13987-13999.


Accessories

Required Accessories

Second Generation Bussey-Saksida Touch Screen Chamber for Rats
Second Generation Bussey-Saksida Touch Screen Chamber for Rats
Model 80604A

The Second Generation Bussey Chambers with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.

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